Current Openings
Associate Director, Drug Metabolism and Pharmacokinetics/Bioanalytical

Position Summary:

We are currently seeking a Associate Director, Drug Metabolism andPharmacokinetics/Bioanalytical, who will have scientific oversight of one or more of the small molecule discovery projects and will manage the qualitative and quantitative in vitro and in vivo PK/ADME bioanalytical assays. The candidate will be expected to collaborate with Medicinal Chemistry and Pharmacology to develop and execute assays/studies necessary to address key program DMPK issues in order to successfully advance research compounds into development.

Essential Functions:

  • Provide scientific DMPK leadership and strategic direction to research project teams
  • Provide scientific oversight of PK/ADME studies placed at CROs
  • Execute/manage quantitative bioanalysis of plasma and other biological matrices to support pharmacokinetic and in vitro ADME analyses of novel small molecule therapeutics
  • May supervise associate-level DMPK scientists
  • Conduct PK and PK/PD modeling using noncompartmental and compartmental models
  • Organize and maintain research data
  • Present data at project team meetings
  • Ensure that high quality research reports are completed in a timely manner

Preferred Experience and Education:

  • PhD in a scientific discipline or BS/MS with appropriate work experience  
  • 7-10 years (PhD) or 12-15 years (BA/MS) of postgraduate experience in an industry research and/or development environment is preferred
  • Strong publication record in the area of ADME/PK coupled with a high level of scientific curiosity and analytical thinking skills

Preferred Additional Skills:

  • Should be familiar with ABI Analyst, Excel, WinNonlin Phoenix and Prism
  • Prior success demonstrating strong leadership, collaboration and influence throughout the organization
  • Prior management experience of Research Associates and/or Scientists is a plus
  • Strong bioanalytical method development skills (HPLC and LC/MS/MS)
  • Experience conducting microsomal, plasma and whole blood stability determinations, metabolite profiling, CYP and transporter inhibition studies, and plasma protein binding analyses
  • Be able to work independently and in a cross-functional team environment
  • Must have solid knowledge and demonstrated hands-on experience in qualitative and quantitative bioanalysis and in vitro assay development  
  • Strong verbal, written communication and relationship skills including success managing external vendors
  • Excellent interpersonal and organizational skills
  • Engaged in LC/MS/MS instrument maintenance and repair
  • Detail-oriented and have an in-depth understanding of industry trends
  • Success operating in a fast-paced, dynamic environment
  • Current US work authorization required
  • Ability to travel domestically